Analysis Tools
growth/size/body
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• older mice show mild heart enlargement, most likely due to compensatory response to compromised heart function
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• hearts exhibit normal weight in young mice (14-weeks-old) but are 31% heavier than controls in old mice (50-weeks old)
• however, body weight is normal at 13-20 weeks of age
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cardiovascular system
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• heart mitochondria exhibit fragmented cristae
• mean size of heart mitochondria is 1.5 times larger than in controls at 14 weeks of age and 1.7 times larger at 50 weeks of age
• 50-week-old heart mitochondria are 17% larger than 14-week-old mitochondria
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• older mice show mild heart enlargement, most likely due to compensatory response to compromised heart function
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• hearts exhibit normal weight in young mice (14-weeks-old) but are 31% heavier than controls in old mice (50-weeks old)
• however, body weight is normal at 13-20 weeks of age
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• hearts show a mild increase in lactate levels, which may indicate that glycolysis activity is enhanced
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• echocardiography shows that relative mass of the left ventricle tends (not significantly) to be larger in older mice, but is normal in young mice, left ventricle volume is decreased in the systolic phase of hearts at 14 weeks of age, ejection fraction tends to be increased (not significantly), and the left ventricle thickness is increased in the systolic phase of 50-week-old heart, indicating enhanced heart contraction
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cellular
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• heart mitochondria exhibit fragmented cristae
• mean size of heart mitochondria is 1.5 times larger than in controls at 14 weeks of age and 1.7 times larger at 50 weeks of age
• 50-week-old heart mitochondria are 17% larger than 14-week-old mitochondria
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• heart mitochondria show a decrease of complex IV at 14 and 50 weeks of age and a decrease in the steady-state level of MT-CO1 protein, a mtDNA-encoded complex IV protein
• 14-week-old heart mitochondria show a decrease in complex IV activity and 50-week-old heart mitochondria show an additional decrease in complex I activity compared to 14-week old hearts
• however, the steady-state levels of mt-mRNAs are not affected
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muscle
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• heart mitochondria exhibit fragmented cristae
• mean size of heart mitochondria is 1.5 times larger than in controls at 14 weeks of age and 1.7 times larger at 50 weeks of age
• 50-week-old heart mitochondria are 17% larger than 14-week-old mitochondria
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