Phenotypes associated with this allele

• Allele Symbol: Kcnh8^tm1.1Jmn
• Allele Name: targeted mutation 1.1, Jeanne M Nerbonne
• Allele ID: MGI:7734730
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnh8^tm1.1Jmn/Kcnh8^tm1.1Jmn	involves: C57BL/6J	MGI:7734731
cx2	Kcnh3^tm1.2Tije/Kcnh3^tm1.2Tije Kcnh8^tm1.1Jmn/Kcnh8^tm1.1Jmn	involves: C57BL/6 * C57BL/6J	MGI:7734732

Genotype
MGI:7734731

hm1

• Allelic Composition: Kcnh8^tm1.1Jmn/Kcnh8^tm1.1Jmn
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal single cell response ( J:354329 )

• absence of the normal day-night difference in mean repetitive firing rates of suprachiasmatic nucleus neurons resulting from a selective increase in nighttime firing rates

• no significant difference in mean +/- SEM input resistances, resting membrane potentials, and interspike intervals measured in daytime and nighttime unlike in wild-type neurons reflecting higher mean input resistances and depolarized membrane potentials in the nighttime

behavior/neurological

behavior/neurological phenotype ( J:354329 )

• despite loss of day-night difference in neuron firing rates, wheel running circadian rhythms are similar to wild-type controls

Genotype
MGI:7734732

cx2

• Allelic Composition: Kcnh3^tm1.2Tije/Kcnh3^tm1.2Tije; Kcnh8^tm1.1Jmn/Kcnh8^tm1.1Jmn
• Genetic Background: involves: C57BL/6 * C57BL/6J

nervous system

abnormal single cell response ( J:354329 )

• absence of the normal day-night difference in mean repetitive firing rates of suprachiasmatic nucleus neurons resulting from a selective increase in nighttime firing rates

• no significant difference in mean +/- SEM input resistances, resting membrane potentials, and interspike intervals measured in daytime and nighttime unlike in wild-type neurons reflecting higher mean input resistances and depolarized membrane potentials in the nighttime

behavior/neurological

behavior/neurological phenotype ( J:354329 )

N • despite loss of day-night difference in neuron firing rates, wheel running circadian rhythms are similar to wild-type controls