Phenotypes associated with this allele

• Allele Symbol: Secisbp2l^tm1.1Qiu
• Allele Name: targeted mutation 1.1, Mengsheng Qiu
• Allele ID: MGI:7734969
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Olig1^tm1(cre)Rth/Olig1^+ Secisbp2l^tm1.1Qiu/Secisbp2l^tm1.1Qiu	involves: 129S4/SvJaeSor * C57BL/6	MGI:7734972

Genotype
MGI:7734972

cn1

• Allelic Composition: Olig1^tm1(cre)Rth/Olig1⁺; Secisbp2l^tm1.1Qiu/Secisbp2l^tm1.1Qiu
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased oligodendrocyte number ( J:333465 )

• decrease in the number of Plp1+ mature oligodendrocytes from P0 to P15

decreased myelin sheath thickness ( J:333465 )

• in the white matter of the spinal cord at P15

abnormal oligodendrocyte differentiation ( J:333465 )

• decrease in the number of Plp1+ mature oligodendrocytes from P0 to P15

• treatment with a T3 analog (GC-1) but not with T4, stimulates oligodendrocyte differentiation

homeostasis/metabolism

increased thyroxine level ( J:333465 )

• increased T4 levels in brain and spinal cord lysates

decreased triiodothyronine level ( J:333465 )

• decreased T3 levels in brain and spinal cord lysates

behavior/neurological

tremors ( J:333465 )

• strong trembling in tail suspension assays at P15 and at P45