Phenotypes associated with this allele

• Allele Symbol: Rnase4^em2Zpxu
• Allele Name: endonuclease-mediated mutation 2, Zhengping Xu
• Allele ID: MGI:7735216
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rnase4^em2Zpxu/Rnase4^em2Zpxu Tg(Vil1-cre)DNju/0	involves: C57BL/6 * C57BL/6J	MGI:7736346

Genotype
MGI:7736346

cn1

• Allelic Composition: Rnase4^em2Zpxu/Rnase4^em2Zpxu; Tg(Vil1-cre)DNju/0
• Genetic Background: involves: C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to induced colitis ( J:354138 )

• mice show increased susceptibility to dextran sulfate sodium (DSS)-induced colitis, showing greater weight loss, increased activity index, shorter colon length, enhanced intestinal permeability, and more severe histological and cytokine level changes in the colon than in wild-type mice

digestive/alimentary system

digestive/alimentary phenotype ( J:354138 )

N • mice exhibit no intestinal abnormalities under normal physiological conditions

abnormal gut flora balance ( J:354138 )

• mice exhibit alterations in the gut microbiota, with an increased abundance of Mucispirillum and Parasutterella genera in the gut

increased susceptibility to induced colitis ( J:354138 )

• mice show increased susceptibility to dextran sulfate sodium (DSS)-induced colitis, showing greater weight loss, increased activity index, shorter colon length, enhanced intestinal permeability, and more severe histological and cytokine level changes in the colon than in wild-type mice