Phenotypes associated with this allele

• Allele Symbol: Styxl2^tm1.1Nju
• Allele Name: endonuclease-mediated mutation 1.1, Model Animal Research Center of Nanjing University
• Allele ID: MGI:7736257
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Styxl2^tm1.1Nju/Styxl2^tm1.1Nju	involves: C57BL/6 * FVB/N	MGI:7736636

Genotype
MGI:7736636

hm1

• Allelic Composition: Styxl2^tm1.1Nju/Styxl2^tm1.1Nju
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:351096 )

• embryos die between E13.5 and E15.5; no live pups are found after birth

homeostasis/metabolism

hydrops fetalis ( J:351096 )

• at E13.5 and E14.5, some dead fetuses exhibit edema

muscle

abnormal sarcomere morphology ( J:351096 )

• at E14.5, TEM analysis showed severe disruption of the sarcomeric structures in fetal cardiomyocytes

cardiovascular system

abnormal fetal cardiomyocyte morphology ( J:351096 )

• at E14.5, TEM analysis showed severe disruption of the sarcomeric structures in fetal cardiomyocytes