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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gmfgtm1Jyw
targeted mutation 1, Ji-Yang Wang
MGI:7736707
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gmfgtm1Jyw/Gmfgtm1Jyw B6.Cg-Gmfgtm1Jyw MGI:7736713


Genotype
MGI:7736713
hm1
Allelic
Composition		 Gmfgtm1Jyw/Gmfgtm1Jyw
Genetic
Background		 B6.Cg-Gmfgtm1Jyw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gmfgtm1Jyw mutation (0 available); any Gmfg mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased lymphocyte chemotaxis ( J:345500 )
• impaired marginal zone B cell chemotaxis towards S1P
impaired B cell migration ( J:345500 )
• FTY720-mediated marginal zone B cell displacement to follicles is impaired with many cells distributed near but not in follicles
increased IgM level ( J:345500 )
• at 8 but not 40 weeks of age
abnormal marginal zone B cell physiology ( J:345500 )
• impaired chemotaxis towards S1P
• FTY720-mediated marginal zone B cell displacement to follicles is impaired with many cells distributed near but not in follicles
• increased production of NP-specific IgM following immunization with NP-Ficoll compared to similarly immunized wild-type cells

cellular
decreased lymphocyte chemotaxis ( J:345500 )
• impaired marginal zone B cell chemotaxis towards S1P
impaired B cell migration ( J:345500 )
• FTY720-mediated marginal zone B cell displacement to follicles is impaired with many cells distributed near but not in follicles

hematopoietic system
decreased lymphocyte chemotaxis ( J:345500 )
• impaired marginal zone B cell chemotaxis towards S1P
impaired B cell migration ( J:345500 )
• FTY720-mediated marginal zone B cell displacement to follicles is impaired with many cells distributed near but not in follicles
increased IgM level ( J:345500 )
• at 8 but not 40 weeks of age
abnormal marginal zone B cell physiology ( J:345500 )
• impaired chemotaxis towards S1P
• FTY720-mediated marginal zone B cell displacement to follicles is impaired with many cells distributed near but not in follicles
• increased production of NP-specific IgM following immunization with NP-Ficoll compared to similarly immunized wild-type cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory