All Phenotypes Ube2f<tm1c(EUCOMM)Hmgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ube2f^{tm1c(EUCOMM)Hmgu}
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:7738243

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Diras2^em1Gpt/Diras2^em1Gpt Kras^tm4Tyj/Kras⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺ Ube2f^{tm1c(EUCOMM)Hmgu}/Ube2f^{tm1c(EUCOMM)Hmgu}	involves: 129S4/SvJae * C57BL/6	MGI:7738284
cn2	Kras^tm4Tyj/Kras⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺ Ube2f^{tm1c(EUCOMM)Hmgu}/Ube2f^{tm1c(EUCOMM)Hmgu}	involves: 129S4/SvJae * C57BL/6J * C57BL/6N	MGI:7738261
cn3	Ptf1a^tm1(cre)Hnak/Ptf1a⁺ Ube2f^{tm1c(EUCOMM)Hmgu}/Ube2f^{tm1c(EUCOMM)Hmgu}	involves: C57BL/6J * C57BL/6N	MGI:7738262

Allelic Composition	Diras2^em1Gpt/Diras2^em1Gpt Kras^tm4Tyj/Kras⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺ Ube2f^{tm1c(EUCOMM)Hmgu}/Ube2f^{tm1c(EUCOMM)Hmgu}
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Diras2^em1Gpt mutation (0 available); any Diras2 mutation (20 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (31 available)
Ube2f^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Ube2f mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased pancreas tumor incidence ( J:348744 )

• relative to mutant mice wild-type for Diras2

• incidence of pancreatic tumors is similar to mutant mice wild-type for both Diras2 and Ube2f but with fewer stage I and more stage II and III tumors

neoplasm

increased pancreas tumor incidence ( J:348744 )

• relative to mutant mice wild-type for Diras2

• incidence of pancreatic tumors is similar to mutant mice wild-type for both Diras2 and Ube2f but with fewer stage I and more stage II and III tumors

Allelic Composition	Kras^tm4Tyj/Kras⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺ Ube2f^{tm1c(EUCOMM)Hmgu}/Ube2f^{tm1c(EUCOMM)Hmgu}
Genetic Background	involves: 129S4/SvJae * C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (31 available)
Ube2f^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Ube2f mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:348744 )

• relative to mutant mice wild-type for Ube2f indicating improved growth

neoplasm

decreased tumor incidence ( J:348744 )

• decrease in pancreatic intraepithelial neoplasia at all 3 stages relative to mutant mice wild-type for Ube2f at 4, 6, and 9 months of age

• by 12 months of age there is an increase in stage I but decrease in stage II and III lesions in the pancreas indicating a delay in pancreatic tumor progression

endocrine/exocrine glands

small pancreas ( J:348744 )

• relative to mutant mice wild-type for Ube2f

decreased susceptibility to induced pancreatitis ( J:348744 )

• decrease in disruption of acinar cell population in cerulein-induced pancreatitis

• fewer infiltrations of leukocytes and neutrophils at 3d after cerulein treatment

Allelic Composition	Ptf1a^tm1(cre)Hnak/Ptf1a⁺ Ube2f^{tm1c(EUCOMM)Hmgu}/Ube2f^{tm1c(EUCOMM)Hmgu}
Genetic Background	involves: C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (31 available)
Ube2f^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Ube2f mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:348744 )

N	• no detectable change in cerulein-induced pancreatitis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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