Phenotypes associated with this allele

• Allele Symbol: Tox2^em1Cdon
• Allele Name: endonuclease-mediated mutation 1, Chen Dong
• Allele ID: MGI:7738442
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tox2^em1Cdon/Tox2^em1Cdon	C57BL/6J-Tox2^em1Cdon	MGI:7738454

Genotype
MGI:7738454

hm1

• Allelic Composition: Tox2^em1Cdon/Tox2^em1Cdon
• Genetic Background: C57BL/6J-Tox2^em1Cdon

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T follicular helper cell differentiation ( J:290926 )

• mice immunized with keyhole limpet hemocyanin (KLH) in complete Freunds adjuvant (CFA) show a modest decrease in T follicular helper cells on day 7 and significantly decreased on day 13

• however, both T cells and B cells are developmentally intact in the thymus and peripherally

decreased germinal center B cell number ( J:290926 )

• mice immunized with NP-KLH in CFA show a significant decrease in the percentage of germinal center B cells on day 13, but not day 7, after immunization

immune system

abnormal T follicular helper cell differentiation ( J:290926 )

• mice immunized with keyhole limpet hemocyanin (KLH) in complete Freunds adjuvant (CFA) show a modest decrease in T follicular helper cells on day 7 and significantly decreased on day 13

• however, both T cells and B cells are developmentally intact in the thymus and peripherally

decreased germinal center B cell number ( J:290926 )

• mice immunized with NP-KLH in CFA show a significant decrease in the percentage of germinal center B cells on day 13, but not day 7, after immunization