Phenotypes associated with this allele

• Allele Symbol: Scd4^tm1.1Ntam
• Allele Name: targeted mutation 1.1, James M Ntambi
• Allele ID: MGI:7738724
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scd4^tm1.1Ntam/Scd4^tm1.1Ntam	involves: C57BL/6	MGI:7856897

Genotype
MGI:7856897

hm1

• Allelic Composition: Scd4^tm1.1Ntam/Scd4^tm1.1Ntam
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal physiological neovascularization ( J:345295 )

♂ • after induction of myocardial infarction (MI) by left coronary artery ligation, mice exhibit a decrease in VEGF-A protein levels in the myocardium and plasma and show lower serum levels of proangiogenic cytokines (IL1-beta, IL-6, TNF-alpha, MCP-1, SDF-1alpha, and Rantes) than sham controls

♂ • after MI, mice show a decrease in the serum content of PDGF-AB/PDGF-BB and fail to exhibit an increase in serum MMP9 levels, unlike wild-type controls

♂ • however, the post-MI levels of TIMP-1 (an anti-angiogenic cytokine) are similar to those in wild-type controls

homeostasis/metabolism

decreased NAD(P)H oxidase activity ( J:345295 )

♂ • after MI, mice show a markedly smaller increase in the protein levels of p47-phox and p91-phox (the two subcomponents of NADPH oxidase) in the infarcted myocardium than wild-type controls

abnormal lipid metabolism ( J:345295 )

♂ • after MI, mice fail to show AMPK activation in the infarcted heart, unlike wild-type controls