Phenotypes associated with this allele

• Allele Symbol: Cox8c^em1Osb
• Allele Name: endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• Allele ID: MGI:7738840
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cox8c^em1Osb/Cox8c^em1Osb	B6;D2-Cox8c^em1Osb/Osb	MGI:7751119
cx2	Cox8c^em1Osb/Cox8c^em1Osb Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0	involves: C57BL/6NJcl * DBA/2NJcl	MGI:7751120

Genotype
MGI:7751119

hm1

• Allelic Composition: Cox8c^em1Osb/Cox8c^em1Osb
• Genetic Background: B6;D2-Cox8c^em1Osb/Osb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:345850 )

N • both female and male homozygotes are fertile

N • male homozygotes show no significant differences in gross testis morphology, average testis weight, testis histology, number of pups produced per plug, sperm mitochondrial function or sperm motility relative to wild-type controls

cellular

cellular phenotype ( J:345850 )

N • under non-capacitation conditions, cauda epididymal sperm show a normal oxygen consumption rate (OCR) with no differences in basal respiration, ATP production, proton leak, maximal respiration or spare capacity relative to wild-type sperm, indicating normal sperm mitochondrial function

N • cauda epididymal sperm show normal motility (%), progressive sperm rate (%), VAP (average-path velocity), VCL (curvilinear velocity), and VSL (straight-line velocity) at both 10 min and 120 min after incubation in TYH capacitation medium; flagellar waveforms are normal at 10 min after incubation

Genotype
MGI:7751120

cx2

• Allelic Composition: Cox8c^em1Osb/Cox8c^em1Osb; Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
• Genetic Background: involves: C57BL/6NJcl * DBA/2NJcl

reproductive system

reproductive system phenotype ( J:345850 )

♂N • cauda epididymal sperm show no abnormalities in mitochondrial sheath formation