Phenotypes associated with this allele

• Allele Symbol: Saa^em1.1Hiras
• Allele Name: endonuclease-mediated mutation 1.1, Sachie Hiratsuka
• Allele ID: MGI:7763990
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Saa^em1.1Hiras/Saa^em1.1Hiras	involves: C57BL/6	MGI:7764021
cx2	Saa^em1.1Hiras/Saa^em1.1Hiras Tg(SAA)#Hiras/0	involves: C57BL/6 * C57BL/6J	MGI:7764023

Genotype
MGI:7764021

hm1

• Allelic Composition: Saa^em1.1Hiras/Saa^em1.1Hiras
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

abnormal tumor pathology ( J:355692 )

• in mice injected with Lewis lung carcinoma cells, fibrinogen deposition in the lungs is decreased compared to similarly treated wild-type mice

• detection of citrullinated fibrinogen in tumor bearing mice is rare unlike in tumor bearing wild-type mice

decreased metastatic potential ( J:355692 )

• when injected with a spontaneous metastatic Lewis lung carcinoma cell line (3LL) lung metastasis is less severe at 3 weeks post treatment than in similarly treated wild-type mice

reproductive system

reproductive system phenotype ( J:355692 )

N • no apparent abnormalities in fertility

mortality/aging

mortality/aging ( J:355692 )

N • no apparent abnormalities in viability, maturation, or appearance

Genotype
MGI:7764023

cx2

• Allelic Composition: Saa^em1.1Hiras/Saa^em1.1Hiras; Tg(SAA)#Hiras/0
• Genetic Background: involves: C57BL/6 * C57BL/6J

neoplasm

increased metastatic potential ( J:355692 )

• marked increase in human metastatic tumor cells in mice treated with citrullinated fibrinogen, but not when treated with fibrinogen, compared to similarly treated null mice not carrying the transgene