Phenotypes associated with this allele

• Allele Symbol: Ppid^em1Cask
• Allele Name: endonuclease-mediated mutation 1, Kevin M Casin
• Allele ID: MGI:7779593
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppid^em1Cask/Ppid^em1Cask	Not Specified	MGI:7779599

Genotype
MGI:7779599

hm1

• Allelic Composition: Ppid^em1Cask/Ppid^em1Cask
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitochondrial physiology ( J:358023 )

• calcium retention capacity is increased ~4 fold in mitochondria from hearts

• results indicate impaired permeability transition pore activity

cardiovascular system

increased susceptibility to myocardial ischemic injury ( J:358023 )

• isolated hearts subjected to ischemia-reperfusion display larger infarcts and poorer post-ischemic functional recoveries

homeostasis/metabolism

increased susceptibility to myocardial ischemic injury ( J:358023 )

• isolated hearts subjected to ischemia-reperfusion display larger infarcts and poorer post-ischemic functional recoveries