All Phenotypes Gigyf1<em1Xio> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gigyf1^em1Xio
endonuclease-mediated mutation 1, Bo Xiong
MGI:7779906

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gigyf1^em1Xio/Gigyf1^em1Xio Neurod6^tm1(cre)Kan/Neurod6⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:7779933
cn2	Gigyf1^em1Xio/Gigyf1^em1Xio Gad2^tm2(cre)Zjh/Gad2⁺	involves: 129S4/SvJae * C57BL/6	MGI:7779934

Allelic Composition	Gigyf1^em1Xio/Gigyf1^em1Xio Neurod6^tm1(cre)Kan/Neurod6⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gigyf1^em1Xio mutation (0 available); any Gigyf1 mutation (28 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal short-term spatial reference memory ( J:335507 )

• mice show a minor deficit in short-term memory in the T-maze test

decreased social novelty preference ( J:335507 )

• mice have normal sociability during a social interaction session but show a deficit in the social novelty test, with reduced ability to discriminate novel and familiar conspecifics and impaired social memory

increased grooming behavior ( J:335507 )

• mice exhibit repetitive behavior with excessive grooming

• however, mice do not show changes in the open field, novel object recognition, rearing, marble burying, elevated plus maze, or fear conditioning tests

impaired social recognition ( J:335507 )

Allelic Composition	Gigyf1^em1Xio/Gigyf1^em1Xio Gad2^tm2(cre)Zjh/Gad2⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gad2^tm2(cre)Zjh mutation (3 available); any Gad2 mutation (60 available)
Gigyf1^em1Xio mutation (0 available); any Gigyf1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal object recognition memory ( J:335507 )

• mice exhibit an impairment in cognitive performance in the novel object recognition test

• however, mice do not show changes in sociability, social novelty, rearing, marble burying, elevated plus maze, or T-maze

increased thigmotaxis ( J:335507 )

• mice exhibit elevated anxiety levels, spending less time in centers of the open field

decreased grooming behavior ( J:335507 )

• mice exhibit reduced grooming behavior

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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