Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gigyf1em1.1Xio endonuclease-mediated mutation 1.1, Bo Xiong MGI:7779907 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice have normal sociability during a social interaction session but show a deficit in the social novelty test, with an inability to discriminate novel and familiar conspecifics and impaired social memory
• however, no differences in anxiety in the open field, novel object recognition, rearing, marble burying, T-maze or elevated plus maze are seen
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• mice exhibit repetitive behavior with excessive grooming
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• locomotion activity is slightly decreased in the open field
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• mice have normal sociability during a social interaction session but show a deficit in the social novelty test, with an inability to discriminate novel and familiar conspecifics and impaired social memory
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• mice exhibit a higher percentage of Slc17a7+ (Vglut1+) excitatory neurons in the CA2-CA3 region
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• density of NeuN+ neurons in the CA2 region is increased, indicating increased CA2 glutamatergic neurons
• however, synapse density is normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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