Phenotypes associated with this allele

• Allele Symbol: B4galt3^em1Masn
• Allele Name: endonuclease-mediated mutation 1, Masahide Asano
• Allele ID: MGI:7780011
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	B4galt3^em1Masn/B4galt3^em1Masn	C57BL/6-B4galt3^em1Masn	MGI:7780184

Genotype
MGI:7780184

hm1

• Allelic Composition: B4galt3^em1Masn/B4galt3^em1Masn
• Genetic Background: C57BL/6-B4galt3^em1Masn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased tumor growth/size ( J:343168 )

• females injected with strongly immunogenic breast adenocarcinoma E0771 tumor cells and colon carcinoma MC38 tumor cells exhibit slower tumor growth than in wild-type mice

• however, growth rate of injected weakly immunogenic melanoma B16F10 and bladder carcinoma MB49 tumor cells are not changed from that seen in wild-type mice

• mice exhibit growth suppression of B16F10 tumors expressing the immunogenic model antigen ovalbumin but not B16F10 tumors

• wild-type mice engrafted with knock-out bone marrow cells show suppressed growth of strongly immunogenic MC38 tumors compared to wild-type mice engrafted with wild-type bone marrow cells

• mice treated with antibody to deplete CD8+ T cells show no change in tumor growth rate of injected MC38 tumor cells indicating that CD8+ T cells are essential for suppressing tumor growth

hematopoietic system

increased CD8-positive, alpha-beta T cell number ( J:343168 )

• the tumor immune microenvironment of mice transplanted with E0771 tumor cells exhibits more infiltration of IFN-gamma+ and granzyme B+ CD8+ T cells compared to wild-type cells

• however, no difference in CD4+ T cell infiltration is seen no changes in the infiltration of myeloid-derived suppressor cells, macrophages, NK cells, or dendritic cells are seen

decreased regulatory T cell number ( J:343168 )

• the tumor immune microenvironment of mice transplanted with E0771 tumor cells shows decreased infiltration of regulatory T cells

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:343168 )

• mice transplanted with E0771 tumor cells exhibit enhanced infiltration and cytotoxic activity of CD8+ T cells in the tumor immune microenvironment

immune system

increased CD8-positive, alpha-beta T cell number ( J:343168 )

• the tumor immune microenvironment of mice transplanted with E0771 tumor cells exhibits more infiltration of IFN-gamma+ and granzyme B+ CD8+ T cells compared to wild-type cells

• however, no difference in CD4+ T cell infiltration is seen no changes in the infiltration of myeloid-derived suppressor cells, macrophages, NK cells, or dendritic cells are seen

decreased regulatory T cell number ( J:343168 )

• the tumor immune microenvironment of mice transplanted with E0771 tumor cells shows decreased infiltration of regulatory T cells

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:343168 )

• mice transplanted with E0771 tumor cells exhibit enhanced infiltration and cytotoxic activity of CD8+ T cells in the tumor immune microenvironment