Phenotypes associated with this allele

• Allele Symbol: Wsb1^tm1.1Jszh
• Allele Name: targeted mutation 1.1, Jin-San Zhang
• Allele ID: MGI:7782525
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Wsb1^tm1.1Jszh/Wsb1^tm1.1Jszh Ubc^em1(cre/ERT2)Smoc/Ubc^+	involves: C57BL/6J * C57BL/6N	MGI:7782598

Genotype
MGI:7782598

cn1

• Allelic Composition: Wsb1^tm1.1Jszh/Wsb1^tm1.1Jszh; Ubc^{em1(cre/ERT2)Smoc}/Ubc⁺
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to injury ( J:358004 )

• tamoxifen-treated mice treated with an intratracheal instillation of bleomycin to induce lung injury show reduced severity of pulmonary fibrosis, lower lung inflammation and induction of TNF-alpha and TGF-beta expression, improved weight gain after the initial loss, reduced apoptotic cells, inhibited lipofibroblast-to-myofibroblast transdifferentiation, and enhanced alveolar type 2 cell proliferation and differentiation into alveolar type 1, enhancing alveolar repair

immune system

decreased inflammatory response ( J:358004 )

• tamoxifen-treated mice intratracheally installed with bleomycin show lower lung inflammation and fibrosis and lower induction of TNF-alpha and TGF-beta expression indicating amelioration of bleomycin-induced pulmonary inflammation

respiratory system

abnormal type II pneumocyte morphology ( J:358004 )

• tamoxifen-treated mice with bleomycin-induced lung injury show enhanced alveolar type 2 cell proliferation and enhanced alveolar type 2 to alveolar type 1 differentiation, enhancing alveolar repair

cellular

decreased apoptosis ( J:358004 )

• tamoxifen-treated mice with bleomycin-induced lung injury show a reduction in apoptotic cells

abnormal myofibroblast differentiation ( J:358004 )

• lipofibroblast-to-myofibroblast transdifferentiation in the lungs is inhibited in tamoxifen-treated mice with bleomycin-induced lung fibrosis