All Phenotypes Fam50a<em1Zfhu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fam50a^em1Zfhu
endonuclease-mediated mutation 1, Zhangfeng Hu
MGI:7783439

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fam50a^em1Zfhu/Y Stra8^{em1(GFP/cre)Smoc}/Stra8⁺	Not Specified	MGI:7783442

Allelic Composition	Fam50a^em1Zfhu/Y Stra8^{em1(GFP/cre)Smoc}/Stra8⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fam50a^em1Zfhu mutation (0 available); any Fam50a mutation (4 available)
Stra8^{em1(GFP/cre)Smoc} mutation (0 available); any Stra8 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

azoospermia ( J:357849 )

• many seminiferous tubules in P16 and older males are vacuolated due to the absence of spermatocytes and spermatids, as indicated by a lack of XY body formation and absence of PNA signal

• no sperm are seen in adult cauda epididymides

arrest of male meiosis ( J:357849 )

• germ cell development is arrested in meiotic prophase

small testis ( J:357849 )

• testes are smaller at P16 and later

male infertility ( J:357849 )

endocrine/exocrine glands