Phenotypes associated with this allele

• Allele Symbol: Fam50b^em1Zfhu
• Allele Name: endonuclease-mediated mutation 1, Zhangfeng Hu
• Allele ID: MGI:7783440
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fam50b^em1Zfhu/Fam50b^em1Zfhu	C57BL/6J-Fam50b^em1Zfhu	MGI:7783444

Genotype
MGI:7783444

hm1

• Allelic Composition: Fam50b^em1Zfhu/Fam50b^em1Zfhu
• Genetic Background: C57BL/6J-Fam50b^em1Zfhu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm flagellum morphology ( J:357849 )

♂ • cauda epididymal sperm show increased rates of abnormal flagella, including cytoplasmic vacuoles enveloping mitochondria sheath, a complete lack of mitochondrial sheath, two or more cross-sections of the same sperm flagellum enclosed within one cell membrane, partially formed outer dense fibers and abnormal axonemal microtubules

abnormal outer dense fiber morphology ( J:357849 )

♂ • partially formed outer dense fibers

abnormal sperm axoneme morphology ( J:357849 )

♂ • abnormal axonemal microtubules

absent sperm mitochondrial sheath ( J:357849 )

♂ • in some sperm

asthenozoospermia ( J:357849 )

♂ • total motility of sperm is reduced

male infertility ( J:357849 )

♂ • males are sterile

♂ • however, no differences are seen in gross appearance of testis or body or testis weight, and no severe abnormality in the seminiferous epithelial cycle of the testes is seen

cellular

abnormal sperm flagellum morphology ( J:357849 )

♂ • cauda epididymal sperm show increased rates of abnormal flagella, including cytoplasmic vacuoles enveloping mitochondria sheath, a complete lack of mitochondrial sheath, two or more cross-sections of the same sperm flagellum enclosed within one cell membrane, partially formed outer dense fibers and abnormal axonemal microtubules

abnormal outer dense fiber morphology ( J:357849 )

♂ • partially formed outer dense fibers

abnormal sperm axoneme morphology ( J:357849 )

♂ • abnormal axonemal microtubules

absent sperm mitochondrial sheath ( J:357849 )

♂ • in some sperm

asthenozoospermia ( J:357849 )

♂ • total motility of sperm is reduced