Phenotypes associated with this allele

• Allele Symbol: Tulp2^em1Zfhu
• Allele Name: endonuclease-mediated mutation 1, Zhangfeng Hu
• Allele ID: MGI:7783441
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tulp2^em1Zfhu/Tulp2^em1Zfhu	C57BL/6J-Tulp2^em1Zfhu	MGI:7783448

Genotype
MGI:7783448

hm1

• Allelic Composition: Tulp2^em1Zfhu/Tulp2^em1Zfhu
• Genetic Background: C57BL/6J-Tulp2^em1Zfhu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

oligozoospermia ( J:357849 )

♂ • males show reduced caudal epididymal sperm counts

teratozoospermia ( J:357849 )

♂ • more than 70% of sperm are abnormal

abnormal sperm flagellum morphology ( J:357849 )

♂ • malformation of sperm flagella, including disorganized outer dense fibers and the axonemal microtubules

abnormal outer dense fiber morphology ( J:357849 )

♂ • disorganized outer dense fibers

abnormal sperm axoneme morphology ( J:357849 )

♂ • disorganized axonemal microtubules

asthenozoospermia ( J:357849 )

♂ • total motility of sperm is reduced

male infertility ( J:357849 )

♂ • males are sterile

♂ • however, gross testes morphology, body weight and testis weight are normal

cellular

oligozoospermia ( J:357849 )

♂ • males show reduced caudal epididymal sperm counts

teratozoospermia ( J:357849 )

♂ • more than 70% of sperm are abnormal

abnormal sperm flagellum morphology ( J:357849 )

♂ • malformation of sperm flagella, including disorganized outer dense fibers and the axonemal microtubules

abnormal outer dense fiber morphology ( J:357849 )

♂ • disorganized outer dense fibers

abnormal sperm axoneme morphology ( J:357849 )

♂ • disorganized axonemal microtubules

asthenozoospermia ( J:357849 )

♂ • total motility of sperm is reduced