Phenotypes associated with this allele

• Allele Symbol: Arid3c^em1Fclo
• Allele Name: endonuclease-mediated mutation 1, Frederic Clotman
• Allele ID: MGI:7783477
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arid3c^em1Fclo/Arid3c^em1Fclo	Not Specified	MGI:7783569

Genotype
MGI:7783569

hm1

• Allelic Composition: Arid3c^em1Fclo/Arid3c^em1Fclo
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal locomotor behavior ( J:357897 )

• mice show minor defects of the hind paw steps, with differences in stand index (measure for the speed at which the paw loses contact with the glass plate), stand (duration of contact of a paw with the glass plate in a step cycle), swing (duration of absence of contact with the glass plate in a step cycle), and swing speed (speed of the paw during swing) of the hind paws

• the maximum area and the width of the hind paw prints are increased

• the duty cycle, expressed as stance duration as a percentage of the duration of the step cycle of the hind paws, is higher

• however general locomotion (regularity index, base of support of the paws, print positions, percentage of support on one, two, three or four paws) and the different locomotion phases (diagonal, girdle, or ipsilateral phases) are unaltered, general motor coordination is comparable to wild-type mice on the balance beam and rotarod tests, mice exhibit normal forelimb and combined forelimb and hindlimb grip strength, and mice show only a trend toward increased rearing

increased locomotor activity ( J:357897 )

• mice show increased horizonal activity

nervous system

nervous system phenotype ( J:357897 )

N • mice exhibit a normal number of spinal V2 interneurons and V2b interneurons, whatever embryonic stage or level of spinal cord analyzed