Phenotypes associated with this allele

• Allele Symbol: Gstt2^em1Rmah
• Allele Name: endonuclease-mediated mutation 1, Ratha Mahendran
• Allele ID: MGI:7783749
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gstt2^em1Rmah/Gstt2^em1Rmah	Not Specified	MGI:7785104

Genotype
MGI:7785104

hm1

• Allelic Composition: Gstt2^em1Rmah/Gstt2^em1Rmah
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:358834 )

• dendritic cells show enhanced activation and thus stimulation of inflammation in response to Mycobacterium bovis Bacillus CalmetteGuerin (BCG) immunotherapy exposure compared to wild-type dendritic cells

immune system

increased interleukin-10 secretion ( J:358834 )

• bone marrow derived dendritic cells produce more IL10 than wild-type dendritic cells

• however, no difference in dendritic cell production of IL10 after BCG stimulation for 2 our 24 hours is seen

decreased interleukin-12 secretion ( J:358834 )

• bone marrow derived dendritic cells stimulated with BCG immunotherapy for 2 or 24 hours produce less IL12p70 than stimulated wild-type dendritic cells

increased interleukin-12 secretion ( J:358834 )

• bone marrow derived dendritic cells produce more IL12p70 than wild-type dendritic cells

increased interleukin-6 secretion ( J:358834 )

• bone marrow derived dendritic cells stimulated with BCG immunotherapy for 2 or 24 hours, show a 3-fold higher production of IL6 than stimulated wild-type dendritic cells

decreased tumor necrosis factor secretion ( J:358834 )

• bone marrow derived dendritic cells stimulated with BCG for 2 hours produce less TNF-alpha than stimulated wild-type dendritic cells

increased tumor necrosis factor secretion ( J:358834 )

• dendritic cells exposed to BCG for 24 hours show a 7-fold increase in TNF-alpha levels after 24 hours compared to a 2 hour exposure

increased inflammatory response ( J:358834 )

• dendritic cells show enhanced activation and thus stimulation of inflammation in response to BCG immunotherapy exposure