Phenotypes associated with this allele

• Allele Symbol: Trmt10a^em1Tomik
• Allele Name: endonuclease-mediated mutation 1, Kazuhito Tomizawa
• Allele ID: MGI:7785269
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trmt10a^em1Tomik/Trmt10a^em1Tomik	C57BL/6N-Trmt10a^em1Tomik	MGI:7785288

Genotype
MGI:7785288

hm1

• Allelic Composition: Trmt10a^em1Tomik/Trmt10a^em1Tomik
• Genetic Background: C57BL/6N-Trmt10a^em1Tomik

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:358937 )

• mice exhibit lower body weight at P0.5 and during the growth period and adulthood

nervous system

decreased brain weight ( J:358937 )

• brain weight is lower in adults but not at P0.5

abnormal postsynaptic density morphology ( J:358937 )

• postsynaptic density is smaller in the CA1 region of the hippocampus

• however, overall morphological appearance and neuronal distribution in brain tissue, cortical thickness, and presynaptic bouton size are normal

impaired synaptic plasticity ( J:358937 )

• mice exhibit normal induction of hippocampal long-term potentiation (LTP), however maintenance of LTP is disrupted at 60 minutes post-administration of high frequency stimuli suggesting impaired hippocampal neuronal plasticity

• however, no changes in the input-output slope curve in the field excitatory postsynaptic potential (fEPSP)

behavior/neurological

impaired spatial learning ( J:358937 )

• in the Barnes maze test, mice have difficulty learning and memorizing the location of the hidden box, indicating reduced spatial learning ability

abnormal spatial reference memory ( J:358937 )

• in the Barnes maze test, mice have difficulty learning and memorizing the location of the hidden box

impaired coordination ( J:358937 )

• mice cannot continue walking and do not stay on the rotarod, indicting reduced motor coordination

• however, spontaneous locomotor activity and fear-like behaviors in the open-field test are unaffected

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:358937 )

N • mice exhibit normal pancreatic tissue, normal serum amylase levels and normal blood glucose regulation

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:358937 )

N • no differences in the serum levels of growth-related hormones (growth hormone, insulin-like growth factor I, thyroid-stimulating hormone) are seen

liver/biliary system

liver/biliary system phenotype ( J:358937 )

N • mice exhibit normal liver tissue, and normal serum albumin, aspartate transaminase, alanine transaminase, and bilirubin levels

renal/urinary system

renal/urinary system phenotype ( J:358937 )

N • mice exhibit normal kidney tissue and normal levels of serum urea nitrogen, serum creatinine, and urine sodium and potassium levels