All Phenotypes Itih5<tm1Jmba> MGI Mouse

decreased keratinocyte proliferation ( J:359049 )

• in a skin model of dermal fibroblasts and epidermal keratinocytes grown in D3 culture, the keratinocytes show lower proliferation activity

abnormal epidermis stratum corneum morphology ( J:359049 )

• ear skin shows overall a thinner corneum

• in a skin model of dermal fibroblasts and epidermal keratinocytes grown in D3 culture, keratinocytes show no stratified structure and completely lack the stratum corneum

thin epidermis ( J:359049 )

• ear skin shows overall a thinner epidermis

• the epidermis consists of only two cell layers

• in a skin model in which dermal fibroblasts from adults and epidermal keratinocytes from embryos were grown in 3D culture, thickness of the epidermis is reduced

thin skin ( J:359049 )

• ear skin thickness is reduced

increased body fat mass ( J:359016 )

• absolute fat mass of gonadal and perirenal fat pads is increased

abnormal fat cell differentiation ( J:359016 )

• adipogenic differentiation is increased in adipose stem cells

• mice show increased proliferation of adipose stem cells during adipogenic differentiation

abnormal adipose tissue physiology ( J:359016 )

• in an artificial inflammatory environment stimulated by TNF-alpha and Il-1beta exposure, adipose stem cells show greater secretory activity of IL-6 and MCP-1, indicating enhanced inflammatory response

• unstimulated adipose stem cells show increased IL-6 and MCP-1 secretion

abnormal chondrocyte differentiation ( J:359049 )

• adipose stem cells show increased chondrogenic differentiation

• however, osteogenic differentiation is not affected