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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zfp574em3Btlr
endonuclease-mediated mutation 3, Bruce Beutler
MGI:7790454
Summary 2 genotypes


Genotype
MGI:7790547
cn1
Allelic
Composition		 Zfp574em3Btlr/Zfp574em3Btlr
Ndor1Tg(UBC-cre/ERT2)1Ejb/Ndor1+
Genetic
Background		 B6.Cg-Ndor1Tg(UBC-cre/ERT2)1Ejb Zfp574em3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndor1Tg(UBC-cre/ERT2)1Ejb mutation (6 available); any Ndor1 mutation (32 available)
Zfp574em3Btlr mutation (0 available); any Zfp574 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
macrocytic anemia ( J:354285 )
• tamoxifen-treated mice exhibit macrocytic anemia
decreased B cell number ( J:354285 )
• transplantation of a 1:1 mixture of mutant and congenic wild-type bone marrow cells into lethally irradiated CD45.1 recipients that were injected with tamoxifen 12 weeks after bone marrow transplantation exhibit 40.3% elimination of mutant nonmalignant B cells
pancytopenia ( J:354285 )
• tamoxifen-treated mice exhibit pancytopenia with macrocytic anemia
abnormal hematopoietic stem cell morphology ( J:354285 )
• transplantation of a 1:1 mixture of mutant and congenic wild-type bone marrow cells into lethally irradiated CD45.1 recipients that were injected with tamoxifen at 12 weeks posttransplant show rapid deletion of all hematopoietic stem and progenitor cell (HSPC) populations derived specifically from mutant bone marrow; progenitor cell populations are more severely affected that hematopoietic stem cells

immune system
decreased B cell number ( J:354285 )
• transplantation of a 1:1 mixture of mutant and congenic wild-type bone marrow cells into lethally irradiated CD45.1 recipients that were injected with tamoxifen 12 weeks after bone marrow transplantation exhibit 40.3% elimination of mutant nonmalignant B cells




Genotype
MGI:7790549
cn2
Allelic
Composition		 Zfp574em3Btlr/Zfp574em3Btlr
Ndor1Tg(UBC-cre/ERT2)1Ejb/Ndor1+
Tg(IghMyc)22Bri/0
Genetic
Background		 B6.Cg-Ndor1Tg(UBC-cre/ERT2)1Ejb Zfp574em3Btlr Tg(IghMyc)22Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndor1Tg(UBC-cre/ERT2)1Ejb mutation (6 available); any Ndor1 mutation (32 available)
Tg(IghMyc)22Bri mutation (1 available)
Zfp574em3Btlr mutation (0 available); any Zfp574 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:354285 )
• transplantation of a 1:1 mixture of mutant and wild-type bone marrow cells into lethally irradiated CD45.1 recipients that were injected with tamoxifen 12 weeks after bone marrow transplantation exhibit more rapid elimination of leukemic B cells than nonmalignant Zfp574em3Btlr/Zfp574em3Btlr Ndor1Tg(UBC-cre/ERT2)1Ejb mice; up to 79.3% of established leukemic B cells are eliminated after the first dose of tamoxifen and 91.9% of leukemic B cells are eliminated after a second tamoxifen dose

immune system
decreased B cell number ( J:354285 )
• transplantation of a 1:1 mixture of mutant and wild-type bone marrow cells into lethally irradiated CD45.1 recipients that were injected with tamoxifen 12 weeks after bone marrow transplantation exhibit more rapid elimination of leukemic B cells than nonmalignant Zfp574em3Btlr/Zfp574em3Btlr Ndor1Tg(UBC-cre/ERT2)1Ejb mice; up to 79.3% of established leukemic B cells are eliminated after the first dose of tamoxifen and 91.9% of leukemic B cells are eliminated after a second tamoxifen dose

neoplasm
decreased leukemia incidence ( J:354285 )
• transplantation of a 1:1 mixture of mutant and wild-type bone marrow cells into lethally irradiated CD45.1 recipients that were injected with tamoxifen 12 weeks after bone marrow transplantation exhibit more rapid elimination of leukemic B cells than nonmalignant Zfp574em3Btlr/Zfp574em3Btlr Ndor1Tg(UBC-cre/ERT2)1Ejb mice; up to 79.3% of established leukemic B cells are eliminated after the first dose of tamoxifen and 91.9% of leukemic B cells are eliminated after a second tamoxifen dose




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory