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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Eif2ak2em1Btlr
endonuclease-mediated mutation 1, Bruce Beutler
MGI:7790457
Summary 2 genotypes


Genotype
MGI:7790553
hm1
Allelic
Composition		 Eif2ak2em1Btlr/Eif2ak2em1Btlr
Genetic
Background		 C57BL/6J-Eif2ak2em1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak2em1Btlr mutation (0 available); any Eif2ak2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:354285 )
N
• mice exhibit normal lymphocyte and red blood cell counts, normal T cell-dependent and T-cell independent antibody response after immunization with aluminum hydroxide-precipitated ovalbumin or NP-Ficoll, respectively, and normal class switch recombination

immune system
immune system phenotype ( J:354285 )
N
• mice exhibit normal lymphocyte and red blood cell counts, normal T cell-dependent and T-cell independent antibody response after immunization with aluminum hydroxide-precipitated ovalbumin or NP-Ficoll, respectively, and normal class switch recombination




Genotype
MGI:7790551
cx2
Allelic
Composition		 Eif2ak2em1Btlr/Eif2ak2em1Btlr
Zfp574em1Btlr/Zfp574em1Btlr
Genetic
Background		 C57BL/6J-Zfp574em1Btlr Eif2ak2em1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak2em1Btlr mutation (0 available); any Eif2ak2 mutation (41 available)
Zfp574em1Btlr mutation (0 available); any Zfp574 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal hematopoietic system morphology/development ( J:354285 )
• no rescue of lymphocyte deficiencies, anemia, and lymphocyte functional impairments caused by homozygous Zfp574 mutation
abnormal B cell physiology ( J:354285 )
• cell cycle analysis of naive B cells during LPS- and IL-4-induced activation shows an increased frequency of cells arrested in G0/G1 phases with concomitant reduction of cells in S phase compared to wild-type cells
abnormal class switch recombination ( J:354285 )
• splenic naive B lymphocytes in vitro show decreased LPS- and IL-4-induced class switch recombination to IgG1 and cell division

immune system
abnormal B cell physiology ( J:354285 )
• cell cycle analysis of naive B cells during LPS- and IL-4-induced activation shows an increased frequency of cells arrested in G0/G1 phases with concomitant reduction of cells in S phase compared to wild-type cells
abnormal class switch recombination ( J:354285 )
• splenic naive B lymphocytes in vitro show decreased LPS- and IL-4-induced class switch recombination to IgG1 and cell division
abnormal humoral immune response ( J:354285 )
• diminished T cell-independent antibody responses to NP-Ficoll
• diminished T cell-dependent antibody responses to aluminum hydroxide-precipitated ovalbumin




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory