Analysis Tools
growth/size/body
 |
• HFD increases fat mass without altering lean mass in 15-week-old mice on 8 weeks HFD and increases the adiposity index (fat mass/lean mass)
|
|
|
• mice administered a high-fat diet (HFD) over 15-16 weeks from 7 weeks of age show increased body weight during the first 6 weeks of HFD (age 8-14 weeks) but less pronounced difference from week 6 onwards
|
|
|
• mice show a tendency to exhibit increased liver weight on a HFD at the end of the study
|
homeostasis/metabolism
|
|
• mice administered a high-fat diet (HFD) over 15-16 weeks from 7 weeks of age show increased body weight during the first 6 weeks of HFD (age 8-14 weeks) but less pronounced difference from week 6 onwards
|
|
|
• mice fed a chow diet or HFD show hyperinsulinemia
|
|
|
• HFD feeding induces innate immune response activation with increased TNF-alpha levels
|
|
|
• mice show slightly delayed glucose clearance on chow diet without differences on HFD and no alteration in circulating fasted glucose
|
adipose tissue
|
|
• HFD increases fat mass without altering lean mass in 15-week-old mice on 8 weeks HFD and increases the adiposity index (fat mass/lean mass)
|
behavior/neurological
|
|
• mice show a reduction in food intake after 8 weeks on a HFD (15 weeks of age)
|
hematopoietic system
|
|
• HFD feeding induces innate immune response activation with increased circulating monocyte levels
|
|
|
• mice fed a HFD show increased microglia density in the arcuate nucleus of the hypothalamus
|
|
|
• mice exhibit more elongated ramified arcuate nucleus microglia on HFD compared to control diet, with increased branch number, volume and branch length indicating impaired phagocytosis of microglia
|
immune system
|
|
• HFD feeding induces innate immune response activation with increased circulating monocyte levels
|
|
|
• mice fed a HFD show increased microglia density in the arcuate nucleus of the hypothalamus
|
|
|
• mice exhibit more elongated ramified arcuate nucleus microglia on HFD compared to control diet, with increased branch number, volume and branch length indicating impaired phagocytosis of microglia
|
|
|
• HFD feeding induces innate immune response activation with increased TNF-alpha levels
|
|
|
• HFD feeding induces innate immune response activation with increased circulating monocyte and TNF-alpha levels
|
liver/biliary system
|
|
• mice show a tendency to exhibit increased liver weight on a HFD at the end of the study
|
nervous system
|
|
• mice fed a HFD show increased microglia density in the arcuate nucleus of the hypothalamus
|
|
|
• mice exhibit more elongated ramified arcuate nucleus microglia on HFD compared to control diet, with increased branch number, volume and branch length indicating impaired phagocytosis of microglia
|
|
|
• mice fed a HFD show increased microglia density in the arcuate nucleus of the hypothalamus
|
