Phenotypes associated with this allele

• Allele Symbol: Lrp3^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:7794395
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrp3^em1Cya/Lrp3^em1Cya	C57BL/6N-Lrp3^em1Cya/Cya	MGI:7840150

Genotype
MGI:7840150

hm1

• Allelic Composition: Lrp3^em1Cya/Lrp3^em1Cya
• Genetic Background: C57BL/6N-Lrp3^em1Cya/Cya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

increased susceptibility to induced arthritis ( J:345338 )

• mice show a more severe anterior cruciate ligament transection (ACLT)-induced cartilage degeneration at 4 weeks and 8 weeks than wild-type mice

• type II collagen is decreased in the cartilage compared to wild-type mice following ACLT surgery injury

• ectopic osteophytes are increased, joint surfaces are rough and the joint space is reduced following ACLT surgery injury

osteoarthritis ( J:345338 )

• mice show more serious osteoarthritis progression at 12 months of age than wild-type mice, with barely any proteoglycan in the cartilage and decreased type II collagen

osteophytes ( J:345338 )

• ectopic osteophytes are increased following ACLT surgery injury

growth/size/body

decreased susceptibility to diet-induced obesity ( J:345338 )

• mice fed a high cholesterol diet gain less weight than wild-type mice

• however, mice show normal body weight on a regular diet

immune system

increased susceptibility to induced arthritis ( J:345338 )

• mice show a more severe anterior cruciate ligament transection (ACLT)-induced cartilage degeneration at 4 weeks and 8 weeks than wild-type mice

• type II collagen is decreased in the cartilage compared to wild-type mice following ACLT surgery injury

• ectopic osteophytes are increased, joint surfaces are rough and the joint space is reduced following ACLT surgery injury

osteoarthritis ( J:345338 )

• mice show more serious osteoarthritis progression at 12 months of age than wild-type mice, with barely any proteoglycan in the cartilage and decreased type II collagen

behavior/neurological

decreased thermal nociceptive threshold ( J:345338 )

• the hot plate test shows that the pain response is more sensitive than in wild-type mice after ACLT surgery

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:345338 )

• mice fed a high cholesterol diet gain less weight than wild-type mice

• however, mice show normal body weight on a regular diet

increased circulating cholesterol level ( J:345338 )

• mice fed a high cholesterol diet show a greater increase in total cholesterol serum levels than wild-type mice