About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zfp451em1Ssli
endonuclease-mediated mutation 1, Shanshan Liu
MGI:7797788
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zfp451em1Ssli/Zfp451em1Ssli involves: C57BL/6J MGI:7797867
cx2
 		Tg(Wnt1)1Hev/0
Zfp451em1Ssli/Zfp451em1Ssli 		involves: C57BL/6 * SJL MGI:7797789


Genotype
MGI:7797867
hm1
Allelic
Composition		 Zfp451em1Ssli/Zfp451em1Ssli
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp451em1Ssli mutation (0 available); any Zfp451 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
pulmonary fibrosis ( J:351311 )
• mice show exacerbated bleomycin-induced pulmonary fibrosis
abnormal respiratory system physiology ( J:351311 )
• static compliance is lower than those of wild-type mice in response to bleomycin

homeostasis/metabolism
increased hydroxyproline level ( J:351311 )
• higher severity of bleomycin-induced pulmonary fibrosis is characterized by higher levels of hydroxyproline
increased physiological sensitivity to xenobiotic ( J:351311 )
• mice show exacerbated bleomycin-induced pulmonary fibrosis, with lower static compliance of lungs

cellular
abnormal fibroblast physiology ( J:351311 )
• primary lung fibroblasts exhibit increased expression of myofibroblast markers alpha-SMA and Col1, an increase in the percentages of alpha-SMA-positive cells, and increased expression of Col1a1, Col3a1, and Fn1, indicating lung fibroblast activation
increased fibroblast cell migration ( J:351311 )
• primary lung fibroblasts exhibit enhanced capacity for cell migration
• treatment of primary lung fibroblasts with a PDGFB-neutralizing antibody almost completely reduces the enhanced cell migration




Genotype
MGI:7797789
cx2
Allelic
Composition		 Tg(Wnt1)1Hev/0
Zfp451em1Ssli/Zfp451em1Ssli
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Wnt1)1Hev mutation (2 available)
Zfp451em1Ssli mutation (0 available); any Zfp451 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor latency ( J:338905 )
• mice show delayed breast tumor initiation compared to single Tg(Wnt1)1Hev/0 mice

mortality/aging
increased tumor-free survival time ( J:338905 )
• mice show increased overall survival rates compared to single Tg(Wnt1)1Hev/0 mice

immune system
abnormal macrophage morphology ( J:338905 )
• mice exhibit a decrease in CD206+ macrophages compared to single Tg(Wnt1)1Hev/0 mice
decreased chemokine level ( J:338905 )
• tumor tissues express lower levels of CCL5 than those from single Tg(Wnt1)1Hev/0 mice

homeostasis/metabolism
decreased chemokine level ( J:338905 )
• tumor tissues express lower levels of CCL5 than those from single Tg(Wnt1)1Hev/0 mice

hematopoietic system
abnormal macrophage morphology ( J:338905 )
• mice exhibit a decrease in CD206+ macrophages compared to single Tg(Wnt1)1Hev/0 mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory