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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rtf2tm1d(KOMP)Wtsi
targeted mutation 1d, Wellcome Trust Sanger Institute
MGI:7852633
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rtf2tm1d(KOMP)Wtsi/Rtf2tm1d(KOMP)Wtsi involves: C57BL/6 * C57BL/6N * FVB/N * SJL MGI:7852645
cn2
 		Rtf2tm1c(KOMP)Wtsi/Rtf2tm1d(KOMP)Wtsi involves: C57BL/6 * C57BL/6N * FVB/N * SJL MGI:7852646


Genotype
MGI:7852645
hm1
Allelic
Composition		 Rtf2tm1d(KOMP)Wtsi/Rtf2tm1d(KOMP)Wtsi
Genetic
Background		 involves: C57BL/6 * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtf2tm1d(KOMP)Wtsi mutation (0 available); any Rtf2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7852646
cn2
Allelic
Composition		 Rtf2tm1c(KOMP)Wtsi/Rtf2tm1d(KOMP)Wtsi
Genetic
Background		 involves: C57BL/6 * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtf2tm1c(KOMP)Wtsi mutation (0 available); any Rtf2 mutation (17 available)
Rtf2tm1d(KOMP)Wtsi mutation (0 available); any Rtf2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased fibroblast proliferation ( J:360903 )
• slow proliferation of primary MEFs following cre treatment with few cells in S phase
decreased DNA replication ( J:360903 )
• decrease in replication speed and shortening of the inter-origin distance in cre-treated MEFs

homeostasis/metabolism
decreased DNA replication ( J:360903 )
• decrease in replication speed and shortening of the inter-origin distance in cre-treated MEFs




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory