Phenotypes associated with this allele

• Allele Symbol: Rr596^tm1.1Low
• Allele Name: targeted mutation 1.1, Malcolm J Low
• Allele ID: MGI:7853984
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr596^tm1.1Low/Rr596^tm1.1Low	C57BL/6J-Rr596^tm1.1Low	MGI:7855925
cx2	Rr594^em2Mrub/Rr594^em2Mrub Rr596^tm1.1Low/Rr596^tm1.1Low	C57BL/6J-Rr594^em2Mrub Rr596^tm1.1Low	MGI:7855922

Genotype
MGI:7855925

hm1

• Allelic Composition: Rr596^tm1.1Low/Rr596^tm1.1Low
• Genetic Background: C57BL/6J-Rr596^tm1.1Low

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:357475 )

• at age 16 weeks

behavior/neurological

polyphagia ( J:357475 )

♀ • consume 43.1% more food per day than WT

growth/size/body

obese ( J:357475 )

• early-onset extreme obesity

increased body length ( J:357475 )

• at age 16 weeks

increased liver weight ( J:357475 )

• at age 16 weeks

homeostasis/metabolism

increased fasting circulating glucose level ( J:357475 )

♀ • after 4 h fast at age 16 weeks

increased circulating cholesterol level ( J:357475 )

• after overnight fast at age 16 weeks

increased circulating triglyceride level ( J:357475 )

♀ • after overnight fast at age 16 weeks

liver/biliary system

increased liver weight ( J:357475 )

• at age 16 weeks

Genotype
MGI:7855922

cx2

• Allelic Composition: Rr594^em2Mrub/Rr594^em2Mrub; Rr596^tm1.1Low/Rr596^tm1.1Low
• Genetic Background: C57BL/6J-Rr594^em2Mrub Rr596^tm1.1Low

adipose tissue

increased total body fat amount ( J:357475 )

• at age 16 weeks

behavior/neurological

polyphagia ( J:357475 )

• consume 52.2% more food per day than WT

growth/size/body

obese ( J:357475 )

• early-onset extreme obesity

increased body length ( J:357475 )

• at age 16 weeks

increased liver weight ( J:357475 )

• at age 16 weeks

homeostasis/metabolism

increased fasting circulating glucose level ( J:357475 )

♀ • after 4 h fast at age 16 weeks

increased circulating cholesterol level ( J:357475 )

• after overnight fast at age 16 weeks

increased circulating triglyceride level ( J:357475 )

♀ • after overnight fast at age 16 weeks

liver/biliary system

increased liver weight ( J:357475 )

• at age 16 weeks