Phenotypes associated with this allele

• Allele Symbol: Pramel1^em2Liuw
• Allele Name: endonuclease-mediated mutation 2, Wan-Sheng Liu
• Allele ID: MGI:7855637
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pramel1^em2Liuw/Pramel1^em2Liuw Tg(Stra8-icre)1Reb/0	involves: C57BL/6 * FVB/NJ	MGI:7855703

Genotype
MGI:7855703

cn1

• Allelic Composition: Pramel1^em2Liuw/Pramel1^em2Liuw; Tg(Stra8-icre)1Reb/0
• Genetic Background: involves: C57BL/6 * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

oligozoospermia ( J:342835 )

♂ • at 4 months of age but not at P365

abnormal seminiferous tubule morphology ( J:342835 )

♂ • while Sertoli cells-only tubules are not seen there is a low frequency (<1%) of disorganized tubules at P7

♂ • the frequency of disorganized tubules increases with age to 3% and 7% at P21 and P35, respectively

small testis ( J:342835 )

♂ • at 4 months of age

♂ • however, testis size is similar to controls in young males (less than P41) and at P365

decreased litter size ( J:342835 )

♂ • at 4 months of age but not at P365

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:342835 )

♂ • following treatment with exogenous all-trans retinoic acid at P2, the testis index is increased by 6% and the sperm count is increased by 2.5 fold at P41 compared to similarly treated controls

cellular

oligozoospermia ( J:342835 )

♂ • at 4 months of age but not at P365

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:342835 )

♂ • while Sertoli cells-only tubules are not seen there is a low frequency (<1%) of disorganized tubules at P7

♂ • the frequency of disorganized tubules increases with age to 3% and 7% at P21 and P35, respectively

small testis ( J:342835 )

♂ • at 4 months of age

♂ • however, testis size is similar to controls in young males (less than P41) and at P365