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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ak6tm1.1Zhexf
targeted mutation 1.1, Xiaofeng Zheng
MGI:7858964
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ak6tm1.1Zhexf/Ak6tm1.1Zhexf involves: C57BL/6 MGI:7859274
ht2
 		Ak6tm1.1Zhexf/Ak6+ involves: C57BL/6 MGI:7859276
cx3
 		Ak6tm1.1Zhexf/Ak6+
Tg(MMTV-PyVT)634Mul/0 		involves: C57BL/6 * FVB/N MGI:7859290


Genotype
MGI:7859274
hm1
Allelic
Composition		 Ak6tm1.1Zhexf/Ak6tm1.1Zhexf
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ak6tm1.1Zhexf mutation (0 available); any Ak6 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:241160 )
• no homozygotes found at birth




Genotype
MGI:7859276
ht2
Allelic
Composition		 Ak6tm1.1Zhexf/Ak6+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ak6tm1.1Zhexf mutation (0 available); any Ak6 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal ribosome biogenesis ( J:241160 )
• accumulation of 18S-E pre-rRNA in the liver and kidney indicate a block in rRNA processing
abnormal translation ( J:241160 )
• MEFs show a 0.72 fold reduction in protein synthesis
• protein translation in MEFs is not increased in response to insulin stimulation unlike in wild-type MEFs
• however, proliferation is not obviously delayed under standard conditions

liver/biliary system
abnormal liver physiology ( J:241160 )
• accumulation of 18S-E pre-rRNA in liver samples

homeostasis/metabolism
abnormal translation ( J:241160 )
• MEFs show a 0.72 fold reduction in protein synthesis
• protein translation in MEFs is not increased in response to insulin stimulation unlike in wild-type MEFs
• however, proliferation is not obviously delayed under standard conditions

renal/urinary system
abnormal kidney physiology ( J:241160 )
• accumulation of 18S-E pre-rRNA in kidney samples




Genotype
MGI:7859290
cx3
Allelic
Composition		 Ak6tm1.1Zhexf/Ak6+
Tg(MMTV-PyVT)634Mul/0
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ak6tm1.1Zhexf mutation (0 available); any Ak6 mutation (9 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased mammary gland tumor incidence ( J:241160 )
• at 120 days of age only 40% (2 of 5) of mice have tumors compared to tumors present in all controls (transgenic mice wild-type for Ak6) by 70 days of age
increased tumor latency ( J:241160 )
• breast tumors start developing at 90 days of age compared to 70 days of age in transgenic mice wild-type for Ak6

endocrine/exocrine glands
decreased mammary gland tumor incidence ( J:241160 )
• at 120 days of age only 40% (2 of 5) of mice have tumors compared to tumors present in all controls (transgenic mice wild-type for Ak6) by 70 days of age

integument
decreased mammary gland tumor incidence ( J:241160 )
• at 120 days of age only 40% (2 of 5) of mice have tumors compared to tumors present in all controls (transgenic mice wild-type for Ak6) by 70 days of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory