Analysis Tools
reproductive system
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• in stage I-III seminiferous tubules a layer structure of germ cells is present but few flagella are present in the tubule lumen
• almost all sperm flagella show markedly abnormal morphology
• 9+2 microtubule structure, inner dynein arm, outer dynein arm, outer dense fiber, and fibrous sheath are disorganized and scattered
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• axoneme fail to elongate normally and show significant defects from step 4 spermatids onwards
• components are disorganized, doublet microtubules are not formed, and many single microtubules are seen
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• some flagella are short and coiled
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• significant decrease in the number of sperm in the cauda epididymis
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• only a few elongated spermatids are seen in the lumen of stage VII seminiferous tubules
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• completely infertile
• however, testes/body weight ratio is similar to wild-type controls
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cellular
| N |
• no defects in cilia morphology in cells of the ventricles, trachea or oviducts
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|
|
• in stage I-III seminiferous tubules a layer structure of germ cells is present but few flagella are present in the tubule lumen
• almost all sperm flagella show markedly abnormal morphology
• 9+2 microtubule structure, inner dynein arm, outer dynein arm, outer dense fiber, and fibrous sheath are disorganized and scattered
|
|
|
• axoneme fail to elongate normally and show significant defects from step 4 spermatids onwards
• components are disorganized, doublet microtubules are not formed, and many single microtubules are seen
|
|
|
• some flagella are short and coiled
|
|
|
• significant decrease in the number of sperm in the cauda epididymis
|
|
|
• only a few elongated spermatids are seen in the lumen of stage VII seminiferous tubules
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| spermatogenic failure | DOID:0111910 |
OMIM:PS258150 |
J:361529 | |
