Phenotypes associated with this allele

• Allele Symbol: Wdr4^em1Bcgen
• Allele Name: endonuclease-mediated mutation 1, Biocytogen LLC
• Allele ID: MGI:7859739
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wdr4^em1Bcgen/Wdr4^em1Bcgen	involves: C57BL/6J	MGI:7860756

Genotype
MGI:7860756

hm1

• Allelic Composition: Wdr4^em1Bcgen/Wdr4^em1Bcgen
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

short humerus ( J:355649 )

• at P0

short femur ( J:355649 )

• at P0

short limbs ( J:355649 )

• in newborns

skeleton

decreased chondrocyte proliferation ( J:355649 )

• reduced proliferation of chondrocytes in the growth plate

• however, apoptosis of chondrocytes is similar to controls

short humerus ( J:355649 )

• at P0

short femur ( J:355649 )

• at P0

decreased bone mineral density of femur ( J:355649 )

• in the distal femur

decreased trabecular bone volume ( J:355649 )

• decreased trabecular bone volume per tissue volume in the distal femur

decreased osteoblast cell number ( J:355649 )

• decreased number of osteoblasts

• but normal numbers of osteoclasts

decreased trabecular bone thickness ( J:355649 )

• in the distal femur

decreased bone mass ( J:355649 )

• in the distal femur

decreased compact bone mass ( J:355649 )

• in the distal femur

decreased bone ossification ( J:355649 )

• decreased bone formation

• cultured skeletal stem cells induced toward osteogenic differentiation show reduced alkaline phosphatase activity and calcium nodule deposition

cellular

decreased chondrocyte proliferation ( J:355649 )

• reduced proliferation of chondrocytes in the growth plate

• however, apoptosis of chondrocytes is similar to controls

growth/size/body

decreased body size ( J:355649 )

• newborns are smaller with reduced length of body and limbs

• smaller at 6 weeks of age

decreased body weight ( J:355649 )

• at 6 weeks of age

behavior/neurological

abnormal behavior ( J:355649 )

• display neural and behavioral disorders at 6 weeks of age