Phenotypes associated with this allele

• Allele Symbol: Gulp1^tm1.2Kimj
• Allele Name: targeted mutation 1.1, Jung-Eun Kim
• Allele ID: MGI:7865670
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gulp1^tm1.2Kimj/Gulp1^tm1.2Kimj	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:7865675

Genotype
MGI:7865675

hm1

• Allelic Composition: Gulp1^tm1.2Kimj/Gulp1^tm1.2Kimj
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:340688 )

♀N • no significant difference in trabecular or cortical bone parameters compared to controls in females

abnormal osteoclast morphology ( J:340688 )

♂ • reduced size of osteoclasts

abnormal osteoclast differentiation ( J:340688 )

♂ • decreased osteoclast differentiation

increased osteoclast cell number ( J:340688 )

♂ • increase in the number of osteoclasts relative to bone surface

increased bone volume ( J:340688 )

♂ • increased bone volume per tissue volume in the proximal tibia, distal femur, and fourth lumbar vertebra

abnormal compact bone morphology ( J:340688 )

♂ • increased cortical bone area per total tissue area in the tibia but not the femur

increased compact bone thickness ( J:340688 )

♂

increased bone trabecula number ( J:340688 )

♂ • in the proximal tibia, distal femur, and fourth lumbar vertebra

decreased bone trabecular spacing ( J:340688 )

♂ • in the proximal tibia, distal femur, and fourth lumbar vertebra

♂ • however, trabecular thickness is not different from controls

increased bone mass ( J:340688 )

♂ • in the tibia

abnormal skeleton physiology ( J:340688 )

♂ • increased aromatase activity in the bone marrow indicated by the elevated 17beta-estradiol to testosterone ratio

abnormal osteoclast physiology ( J:340688 )

♂ • decrease in the number of resorption pits and percentage of resorbed areas indicating impaired function

♂ • decreased formation of actin rings and microtubules

homeostasis/metabolism

decreased circulating type I collagen C-terminal telopeptide level ( J:340688 )

♂

increased hormone level ( J:340688 )

♂ • increase in the levels of 17beta-estradiol and 2-hydroxyestradiol in the bone marrow

cellular

abnormal osteoclast differentiation ( J:340688 )

♂ • decreased osteoclast differentiation

hematopoietic system

abnormal osteoclast morphology ( J:340688 )

♂ • reduced size of osteoclasts

abnormal osteoclast differentiation ( J:340688 )

♂ • decreased osteoclast differentiation

increased osteoclast cell number ( J:340688 )

♂ • increase in the number of osteoclasts relative to bone surface

abnormal osteoclast physiology ( J:340688 )

♂ • decrease in the number of resorption pits and percentage of resorbed areas indicating impaired function

♂ • decreased formation of actin rings and microtubules

immune system

abnormal osteoclast morphology ( J:340688 )

♂ • reduced size of osteoclasts

abnormal osteoclast differentiation ( J:340688 )

♂ • decreased osteoclast differentiation

increased osteoclast cell number ( J:340688 )

♂ • increase in the number of osteoclasts relative to bone surface

abnormal osteoclast physiology ( J:340688 )

♂ • decrease in the number of resorption pits and percentage of resorbed areas indicating impaired function

♂ • decreased formation of actin rings and microtubules