All Phenotypes Mab21l1<em1Drf> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mab21l1^em1Drf/Mab21l1^em1Drf	C57BL/6JCrl-Mab21l1^em1Drf	MGI:7867734
ht2	Mab21l1^em1Drf/Mab21l1⁺	C57BL/6JCrl-Mab21l1^em1Drf	MGI:7867737

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye morphology ( J:351048 )

• all mice exhibit a severe bilateral panocular eye malformation, including microphthalmia with disorganized anterior and posterior segments

• the most severely affected eyes only have a rudimentary lens and retina and optic nerve aplasia

abnormal anterior eye segment morphology ( J:351048 )

• disorganization of anterior segments

abnormal cornea morphology ( J:351048 )

• abnormalities of the cornea

abnormal lens morphology ( J:351048 )

• disorganization of lens fibers, with hypoplasia or aplasia of the lens

microphthalmia ( J:351048 )

abnormal posterior eye segment morphology ( J:351048 )

• disorganization of posterior segments

abnormal optic nerve morphology ( J:351048 )

• abnormalities of the optic nerve, with the most severely affected eyes having optic nerve aplasia

abnormal retina morphology ( J:351048 )

• severe disorganization retina, with the most severely affected eyes having a rudimentary retina

abnormal uvea morphology ( J:351048 )

• severe disorganization of veal tissue

• hyperplasia of pigmented uveal tissue

abnormal ciliary body morphology ( J:351048 )

• abnormalities of the ciliary body

abnormal iris morphology ( J:351048 )

• abnormalities of the iris

nervous system

abnormal optic nerve morphology ( J:351048 )

• abnormalities of the optic nerve, with the most severely affected eyes having optic nerve aplasia

Allelic Composition	Mab21l1^em1Drf/Mab21l1⁺
Genetic Background	C57BL/6JCrl-Mab21l1^em1Drf

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mab21l1^em1Drf mutation (0 available); any Mab21l1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal optic disk morphology ( J:351048 )

• all mice exhibit anomalous, excavated optic discs, with bilateral penetration in 9 of 13 mice

large optic disk ( J:351048 )

• optic discs are enlarged

• however, intraocular pressure is within the normal range and slit lamp examination of the iris and anterior segment appears normal and mice show no other apparent abnormalities