Analysis Tools
immune system
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• following collagen-induced arthritis (CIA), male mice exhibit a higher arthritis score, more severe paw swelling, and higher histological scores of rheumatoid arthritis (RA) phenotypes including synovial hyperplasia, pannus formation, and cartilage destruction in knee joints, as well as a higher number of SSRP1 (structure specific recognition protein 1)-positive cells in synovial tissues than similarly treated wild-type controls
• intra-articular delivery of adeno-associated virus (AAV)-mediated Ssrp1-shRNA to male mice with CIA ameliorates arthritis scores and paw swelling and attenuates the severity of RA phenotypes resulting in significantly lower scores of synovial hyperplasia, pannus formation, and cartilage destruction in knee joints, supporting that Mir204/Mir211 may play an anti-arthritis effect by modulating Ssrp1 (the downstream target gene of Mir204/211)
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skeleton
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• following collagen-induced arthritis (CIA), male mice exhibit a higher arthritis score, more severe paw swelling, and higher histological scores of rheumatoid arthritis (RA) phenotypes including synovial hyperplasia, pannus formation, and cartilage destruction in knee joints, as well as a higher number of SSRP1 (structure specific recognition protein 1)-positive cells in synovial tissues than similarly treated wild-type controls
• intra-articular delivery of adeno-associated virus (AAV)-mediated Ssrp1-shRNA to male mice with CIA ameliorates arthritis scores and paw swelling and attenuates the severity of RA phenotypes resulting in significantly lower scores of synovial hyperplasia, pannus formation, and cartilage destruction in knee joints, supporting that Mir204/Mir211 may play an anti-arthritis effect by modulating Ssrp1 (the downstream target gene of Mir204/211)
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