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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmem151bnmf389
neuroscience mutagenesis facility, 389
MGI:7868163
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tmem151bnmf389/Tmem151bnmf389 B6N.B6J-Tmem151bnmf389/FrkJ MGI:7868165
hm2
 		Tmem151bnmf389/Tmem151bnmf389 C57BL/6J-Tmem151bnmf389/J MGI:7868199
ht3
 		Tmem151bnmf389/Tmem151b+ B6N.B6J-Tmem151bnmf389/FrkJ MGI:7868187
cx4
 		Tmem151btm1b(KOMP)Wtsi/Tmem151bnmf389 B6N.Cg-Tmem151btm1b(KOMP)Wtsi/Tmem151bnmf389/Frk MGI:7868211


Genotype
MGI:7868165
hm1
Allelic
Composition		 Tmem151bnmf389/Tmem151bnmf389
Genetic
Background		 B6N.B6J-Tmem151bnmf389/FrkJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem151bnmf389 mutation (0 available); any Tmem151b mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
seizures ( J:362012 )
• although homozygotes are not significantly sensitive to kainic acid induced seizures or pentylenetetrazole-induced seizures, they have a reduced threshold for electrically-induced seizures and spontaneous seizures
increased kindling response ( J:362012 )
• From assessments at 6 to 8 weeks of age, females have a mean seizure threshold of 30.31 + 1.73 iRMS compared with 43.16 + 2.21 iRMS for C57BL/6NJ wildtype controls; males have a mean seizure threshold of 34.64 + 0.6 iRMS compared with 47.38 iRMS for C57BL/6NJ wildtype controls.
maximal tonic hindlimb extension seizures ( J:362012 )
• There is a bypass of the minimal seizure endpoint.
tonic-clonic seizures ( J:362012 )
• spontaneous seizures are observed in older mice

nervous system
seizures ( J:362012 )
• although homozygotes are not significantly sensitive to kainic acid induced seizures or pentylenetetrazole-induced seizures, they have a reduced threshold for electrically-induced seizures and spontaneous seizures
increased kindling response ( J:362012 )
• From assessments at 6 to 8 weeks of age, females have a mean seizure threshold of 30.31 + 1.73 iRMS compared with 43.16 + 2.21 iRMS for C57BL/6NJ wildtype controls; males have a mean seizure threshold of 34.64 + 0.6 iRMS compared with 47.38 iRMS for C57BL/6NJ wildtype controls.
maximal tonic hindlimb extension seizures ( J:362012 )
• There is a bypass of the minimal seizure endpoint.
tonic-clonic seizures ( J:362012 )
• spontaneous seizures are observed in older mice
abnormal hippocampus CA1 region morphology ( J:362012 )
• Histology at 6 weeks of age shows fewer dendritic processes in the area between the CA pyramidal cells and the granule cells of the dentate gyrus, with a longer distance from the cell body to the first dendritic branch




Genotype
MGI:7868199
hm2
Allelic
Composition		 Tmem151bnmf389/Tmem151bnmf389
Genetic
Background		 C57BL/6J-Tmem151bnmf389/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem151bnmf389 mutation (0 available); any Tmem151b mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased kindling response ( J:362012 )
• From assessments at 6 to 8 weeks of age, homozygous females have a mean seizure threshold of 35.34 + 2.05 iRMS compared with 41.92 +3.39 iRMS for C57BL/6J wildtype controls; homozygous males have a mean seizure threshold of 41.11 + 2.09 iRMS compared with 47.86 +3.60 iRMS for C57BL/6J wildtype controls.
tonic-clonic seizures ( J:362012 )
• latency to the first spontaneous seizure ranges from 3 months to a year

nervous system
increased kindling response ( J:362012 )
• From assessments at 6 to 8 weeks of age, homozygous females have a mean seizure threshold of 35.34 + 2.05 iRMS compared with 41.92 +3.39 iRMS for C57BL/6J wildtype controls; homozygous males have a mean seizure threshold of 41.11 + 2.09 iRMS compared with 47.86 +3.60 iRMS for C57BL/6J wildtype controls.
tonic-clonic seizures ( J:362012 )
• latency to the first spontaneous seizure ranges from 3 months to a year




Genotype
MGI:7868187
ht3
Allelic
Composition		 Tmem151bnmf389/Tmem151b+
Genetic
Background		 B6N.B6J-Tmem151bnmf389/FrkJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem151bnmf389 mutation (0 available); any Tmem151b mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal seizure response to electrical stimulation ( J:362012 )
• From assessments at 6 to 8 weeks of age, heterozygous females have a mean seizure threshold of 35.49 + 2.85 iRMS compared with 43.16 + 2.21 iRMS for C57BL/6NJ wildtype controls; heterozygous males have a mean seizure threshold of 41.94 + 1.45 iRMS compared with 47.38 iRMS for C57BL/6NJ wildtype controls.

nervous system
abnormal seizure response to electrical stimulation ( J:362012 )
• From assessments at 6 to 8 weeks of age, heterozygous females have a mean seizure threshold of 35.49 + 2.85 iRMS compared with 43.16 + 2.21 iRMS for C57BL/6NJ wildtype controls; heterozygous males have a mean seizure threshold of 41.94 + 1.45 iRMS compared with 47.38 iRMS for C57BL/6NJ wildtype controls.




Genotype
MGI:7868211
cx4
Allelic
Composition		 Tmem151btm1b(KOMP)Wtsi/Tmem151bnmf389
Genetic
Background		 B6N.Cg-Tmem151btm1b(KOMP)Wtsi/Tmem151bnmf389/Frk
Cell Lines EPD0479_2_H11
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem151bnmf389 mutation (0 available); any Tmem151b mutation (19 available)
Tmem151btm1b(KOMP)Wtsi mutation (1 available); any Tmem151b mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased kindling response ( J:362012 )
• From assessments at 6 to 8 weeks of age, compound heterozygous females have a mean seizure threshold of 29.50 + 1.08 iRMS and compound heterozygous males have a mean seizure threshold of 32.01 + 1.62 iRMS, each comparable with homozygous mutants and lower than single heterozygous mutants.

nervous system
increased kindling response ( J:362012 )
• From assessments at 6 to 8 weeks of age, compound heterozygous females have a mean seizure threshold of 29.50 + 1.08 iRMS and compound heterozygous males have a mean seizure threshold of 32.01 + 1.62 iRMS, each comparable with homozygous mutants and lower than single heterozygous mutants.




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03/18/2025
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