Analysis Tools
behavior/neurological
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• males, but not females, at 6 months of age spend approximately 50% less time in the open arms of the elevated plus maze and exhibit a 50% reduction in time leaning over the edge of the arm, indicating increased anxiety-like behavior
• 3-month-old males show only slightly reduced time in the open arms of the elevated plus maze and in leaning time
• the most anxious 3-month-old males as assessed in the elevated plus maze display a mean latency to fall off the rotarod that is significantly shorter than that of the most anxious controls
• however, 6-month-old mice show normal performance in the rotarod test and open field test and the frequency of entry and time spent in the anxiogenic central part of the arena is normal, and no deficits are seen in spatial learning and memory in the Morris water maze
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homeostasis/metabolism
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• males exhibit a decrease in the concentration of glutamate at 12 months of age
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• females exhibit a reduction in glutamine levels in the hippocampus at 12 months of age
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• males exhibit an increase in the concentration of glutamine in the striatum at 12 months of age
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• males exhibit an increase in taurine in the hippocampus at 12 months of age
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• males exhibit a decrease in the concentration of total choline in the striatum at 12 months of age
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nervous system
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• no neuroanatomical anomalies are detectable at 12 months of age
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• males exhibit an increase in the concentration of glutamine and a decrease in the concentration of glutamate and total choline in the striatum at 12 months of age
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• males exhibit an increase in taurine levels and females exhibit a reduction in glutamine levels in the hippocampus at 12 months of age
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