About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tent5dem1Adki
endonuclease-mediated mutation 1, Andrzej Dziembowski
MGI:8164234
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ot1
 		Tent5dem1Adki/Y involves: C57BL/6JTar * CBA/WTar MGI:8164374


Genotype
MGI:8164374
ot1
Allelic
Composition		 Tent5dem1Adki/Y
Genetic
Background		 involves: C57BL/6JTar * CBA/WTar
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tent5dem1Adki mutation (0 available); any Tent5d mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
increased male germ cell apoptosis ( J:360869 )
• male germ cells grown in culture exhibit higher mortality than wild-type germ cells
abnormal testis morphology ( J:360869 )
• degeneration of testes tissue: testes become relatively smaller throughout life resulting from severe tissue structure deterioration such that 28-week-old testes is hollow
abnormal spermatogenesis ( J:360869 )
• abnormalities in the development of primary spermatocytes

cellular
increased male germ cell apoptosis ( J:360869 )
• male germ cells grown in culture exhibit higher mortality than wild-type germ cells

endocrine/exocrine glands
abnormal testis morphology ( J:360869 )
• degeneration of testes tissue: testes become relatively smaller throughout life resulting from severe tissue structure deterioration such that 28-week-old testes is hollow

homeostasis/metabolism




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory