Phenotypes Associated with This Genotype

Genotype
MGI:2174706

• Allelic Composition: Pkd2^tm2Som/Pkd2⁺
• Genetic Background: involves: 129/Sv * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:59314 )

renal/urinary system

kidney cyst ( J:47035 , J:59314 )

• 21% exhibit unilateral renal cysts (J:47035)

• 29% of 62-88 week old heterozygotes have sparse unilateral renal cysts, however none have bilateral cysts or elevated serum urea nitrogen (J:59314)

liver/biliary system

liver cyst ( J:47035 , J:59314 )

• 10% exhibit liver cysts (J:47035)

• 53% of 62-88 week old heterozygotes have liver cysts (J:59314)

growth/size/body

kidney cyst ( J:47035 , J:59314 )

• 21% exhibit unilateral renal cysts (J:47035)

• 29% of 62-88 week old heterozygotes have sparse unilateral renal cysts, however none have bilateral cysts or elevated serum urea nitrogen (J:59314)

liver cyst ( J:47035 , J:59314 )

• 10% exhibit liver cysts (J:47035)

• 53% of 62-88 week old heterozygotes have liver cysts (J:59314)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
polycystic kidney disease 2		DOID:0110859	OMIM:613095	J:59314