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Phenotypes Associated with This Genotype
Genotype
MGI:2174711
Allelic
Composition		 Prnptm1Miy/Prnptm1Miy
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Miy mutation (0 available); any Prnp mutation (142 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to prion infection ( J:69186 )
• resistance to scrapie infection

behavior/neurological
ataxia ( J:32440 )
• after 70 weeks of age
impaired coordination ( J:32440 )
• after 70 weeks of age

nervous system
Purkinje cell degeneration ( J:32440 )
• after 70 weeks of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT Creutzfeldt-Jakob disease DOID:11949 OMIM:123400
 J:69186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory