Phenotypes Associated with This Genotype

Genotype
MGI:2174818

• Allelic Composition: Tg(APPV717F)109Ili/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:23080 , J:127846 , J:165441 )

• deposits of human beta-amyloid are seen in the hippocampus, corpus callosum and cerebral cortex, beginning at 6 - 9 months, and increasing in density with age (J:23080)

• mice develop plaques by 12 months of age in the hippocampus and the outer molecular layer of the dentate gyrus with a subset of plaques positive for fibrillar amyloid (J:127846)

• plaque deposition increases with age with greater than 85% of the hippocampus covered in plaques at 24 months of age (J:127846)

abnormal dentate gyrus morphology ( J:23080 )

• synaptic and dendritic density are reduced in the molecular layer

neurofibrillary tangles ( J:23080 )

• amyoid plaques are associated with distorted neurites

gliosis ( J:23080 )

• the majority of amyloid plaques are surrounded by GFAP-positive reactive astrocytes

homeostasis/metabolism

amyloid beta deposits ( J:23080 , J:127846 , J:165441 )

• deposits of human beta-amyloid are seen in the hippocampus, corpus callosum and cerebral cortex, beginning at 6 - 9 months, and increasing in density with age (J:23080)

• mice develop plaques by 12 months of age in the hippocampus and the outer molecular layer of the dentate gyrus with a subset of plaques positive for fibrillar amyloid (J:127846)

• plaque deposition increases with age with greater than 85% of the hippocampus covered in plaques at 24 months of age (J:127846)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:23080