Phenotypes Associated with This Genotype

Genotype
MGI:2174892

hm1

• Allelic Composition: Sox1^tm1Vep/Sox1^tm1Vep
• Genetic Background: either: (involves: 129/Sv * 129S/SvEv) or (involves: 129S/SvEv * MF1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:46636 )

• high mortality was observed in both genetic backgrounds

behavior/neurological

abnormal parental behavior ( J:46636 )

• animals are unfit to care for their offspring

abnormal sexual interaction ( J:46636 )

• homozygotes of both sexes rarely mate

seizures ( J:46636 )

• mice suffer from spontaneous seizures

nervous system

seizures ( J:46636 )

• mice suffer from spontaneous seizures

vision/eye

abnormal lens development ( J:46636 )

• expression of gamma crystallin genes was reduced by E15.5

abnormal lens vesicle development ( J:46636 )

• induction and fiber cell differentiation occur normally but the fiber cells fail to elongate all the way toward the anterior epithelial wall, leaving a cavity within the lens vesicle

small lens ( J:46636 )

• mutant lens is reduced in size by approximately 20% at E15.5

microphthalmia ( J:46636 )