Phenotypes Associated with This Genotype

Genotype
MGI:2174917

• Allelic Composition: App^tm1Dbo/App^tm1Dbo
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal active avoidance behavior ( J:53824 )

• age-related impairment in conditioned avoidance tests, seen at 10 months of age, but not at 4 months of age

abnormal spatial learning ( J:53824 )

• impairment in watermaze test of spatial learning, both at 4 and 10 months of age

decreased grip strength ( J:25512 )

• significantly reduced grip strength

abnormal locomotor activation ( J:25512 )

• decreased locomotor activity

decreased locomotor activity ( J:53824 )

cardiovascular system

hematoma ( J:241632 )

• hematomas are smaller following experimentally induced intracerebral hemorrhage as compared to wild-type, but are larger than homozygous App^tm1.1Wevn mice

intracerebral hemorrhage ( J:241632 )

• hematomas are smaller following experimentally induced intracerebral hemorrhage as compared to wild-type, but are larger than homozygous App^tm1.1Wevn mice

homeostasis/metabolism

increased susceptibility to induced thrombosis ( J:241632 )

• time to cessation of blood flow following induced carotid artery thrombosis is decreased as compared to wild-type and homozygous App^tm1.1Wevn mice

nervous system

intracerebral hemorrhage ( J:241632 )

• hematomas are smaller following experimentally induced intracerebral hemorrhage as compared to wild-type, but are larger than homozygous App^tm1.1Wevn mice

gliosis ( J:25512 )

• reactive gliosis was observed throughout the cortical layers of the neocortex and extensive astrogliosis was seen in the CA1 region of the hippocampus, however did not observe neuronal cell damage

astrocytosis ( J:53824 )

• reactive astrocytosis in many brain areas, but predominantly in the cortex and hippocampus at 14 weeks of age

abnormal neuron morphology ( J:53824 )

• the branching of dendrites of both cortical and hippocampal neurons was much less extensive, however did not show any loss of cells in the cortex or the hippocampus

abnormal long-term potentiation ( J:53824 )

• impairment of ability of high frequency stimuli to induce LTP which correlated with extent of gliosis in stratum radiatum

growth/size/body

decreased body weight ( J:25512 )

• body weight was 15-20% less at all ages compared with that of controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:53824