Phenotypes Associated with This Genotype

Genotype
MGI:2174933

• Allelic Composition: Aqp3^tm1Ask/Aqp3^tm1Ask
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

decreased urine osmolality ( J:61675 )

• urine osmolality is decreased to 262 milliosmol compared to 1270 milliosmol in wild-type mice

• following 36 hour water deprivation or 1-desamino-8-D-arginine-vasopressin treatment increase in urine osmolality is much less than that in wild-type mice

abnormal renal water transport ( J:61675 )

• the osmotic water permeability of the basolateral membrane of cortical collecting ducts is decreased at least 3-fold compared to wild-type mice

• expression of Aqp2 is decreased particularly in the renal cortex; however expression of Aqp1 and Aqp4 is similar to wild-type

polyuria ( J:61675 )

• about a 10-fold increase in urine output; however, kidney and urinary bladder morphology are similar to wild-type

behavior/neurological

polydipsia ( J:61675 )

• about a 10-fold increase in fluid consumption

homeostasis/metabolism

increased blood osmolality ( J:61675 )

• plasma osmolality is mildly elevated but serum electrolyte, urea, creatinine, and phosphorus levels are similar to wild-type

decreased circulating triglyceride level ( J:61675 )

decreased urine osmolality ( J:61675 )

• urine osmolality is decreased to 262 milliosmol compared to 1270 milliosmol in wild-type mice

• following 36 hour water deprivation or 1-desamino-8-D-arginine-vasopressin treatment increase in urine osmolality is much less than that in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
nephrogenic diabetes insipidus		DOID:12387		J:61675