Phenotypes Associated with This Genotype

Genotype
MGI:2175020

• Allelic Composition: Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

microgliosis ( J:112713 )

• numbers of microglial cells significantly increased relative to controls after epileptic stimulation

increased circulating tumor necrosis factor level ( J:45147 )

• two hours post i.v. lipopolysaccharide (LPS) challenge serum levels are 5 fold higher than controls, however, TNF kinetics and activity are not altered

increased inflammatory response ( J:45147 )

• increased pulmonary neutrophil accumulation in response to intranasal instillation of M. faeni as compared to control, however monocyte and lymphocyte levels are comparable to control

lung inflammation ( J:120174 )

• increased numbers of T-gamma,delta cells in broncho-alveolar lavage fluid

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:59056 )

N • normal recovery after superficial injury causes an increased trans-epidermal water loss

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:78637 )

• 41% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%)

increased circulating tumor necrosis factor level ( J:45147 )

• two hours post i.v. lipopolysaccharide (LPS) challenge serum levels are 5 fold higher than controls, however, TNF kinetics and activity are not altered

nervous system

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:78637 )

• 41% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%)

microgliosis ( J:112713 )

• numbers of microglial cells significantly increased relative to controls after epileptic stimulation

abnormal glutamate-mediated receptor currents ( J:152590 )

• increased glutamate currents

neoplasm

increased skin papilloma incidence ( J:89088 )

• development after DMPA/TPA treatment is reduced

respiratory system

lung inflammation ( J:120174 )

• increased numbers of T-gamma,delta cells in broncho-alveolar lavage fluid

hematopoietic system

microgliosis ( J:112713 )

• numbers of microglial cells significantly increased relative to controls after epileptic stimulation

integument

increased skin papilloma incidence ( J:89088 )

• development after DMPA/TPA treatment is reduced

cellular

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:78637 )

• 41% loss of striatal dopaminergic neurons in MPTP model of Parkinson's disease (controls lose 70%)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	essential hypertension	DOID:10825	OMIM:145500 OMIM:603918 OMIM:604329 OMIM:607329 OMIM:608742 OMIM:610261 OMIM:610262 OMIM:610948 OMIM:611014	J:45147
NOT	familial combined hyperlipidemia	DOID:13809	OMIM:144250	J:45147