Phenotypes Associated with This Genotype

Genotype
MGI:2175029

• Allelic Composition: Foxn1^nu-Y/Foxn1^nu-Y
• Genetic Background: 101/HY-Foxn1^nu-Y

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:4060 )

• homozygotes represent about 10.6% of pups from matings of heterozygotes

growth/size/body

decreased body weight ( J:4060 )

• about half normal at 3 weeks of age

immune system

abnormal thymus development ( J:4060 )

• two rudimentary lobules of thymus in apical mediastinum lack a developed stroma and lymphoid infiltration

• almost completely replaced with adipose and mucoid cells by 7.5 weeks of age

athymia ( J:4060 , J:29022 )

• at 11 days (J:4060)

absent T cells ( J:4060 )

• absence of mature T-cells although precursors present in bone marrow

hematopoietic system

abnormal thymus development ( J:4060 )

• two rudimentary lobules of thymus in apical mediastinum lack a developed stroma and lymphoid infiltration

• almost completely replaced with adipose and mucoid cells by 7.5 weeks of age

athymia ( J:4060 , J:29022 )

• at 11 days (J:4060)

absent T cells ( J:4060 )

• absence of mature T-cells although precursors present in bone marrow

integument

hairless ( J:4060 )

endocrine/exocrine glands

abnormal thymus development ( J:4060 )

• two rudimentary lobules of thymus in apical mediastinum lack a developed stroma and lymphoid infiltration

• almost completely replaced with adipose and mucoid cells by 7.5 weeks of age

athymia ( J:4060 , J:29022 )

• at 11 days (J:4060)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
T-cell immunodeficiency, congenital alopecia, and nail dystrophy		DOID:0060769	OMIM:601705	J:29022