Phenotypes Associated with This Genotype

Genotype
MGI:2175031

• Allelic Composition: Foxn1^tm1Tbo/Foxn1^tm1Tbo
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal thymus morphology ( J:33796 )

abnormal thymus development ( J:33796 )

• thymic rudiment in the mediastinum above the heart

abnormal thymus epithelium morphology ( J:177992 )

• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked

• cortical epithelial primordia do not develop

athymia ( J:33796 )

abnormal leukocyte cell number ( J:33796 )

increased B cell number ( J:33796 )

• 2 fold increase in splenic B cells but meseteric lymph node frequency remains unchanged

absent T cells ( J:33796 )

• complete absence of alpha/beta T-cells

hematopoietic system

abnormal thymus morphology ( J:33796 )

abnormal thymus development ( J:33796 )

• thymic rudiment in the mediastinum above the heart

abnormal thymus epithelium morphology ( J:177992 )

• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked

• cortical epithelial primordia do not develop

athymia ( J:33796 )

abnormal leukocyte cell number ( J:33796 )

increased B cell number ( J:33796 )

• 2 fold increase in splenic B cells but meseteric lymph node frequency remains unchanged

absent T cells ( J:33796 )

• complete absence of alpha/beta T-cells

integument

hairless ( J:33796 )

abnormal hair follicle development ( J:61394 )

• loss of expression of some but not all hair keratin genes

endocrine/exocrine glands

abnormal thymus morphology ( J:33796 )

abnormal thymus development ( J:33796 )

• thymic rudiment in the mediastinum above the heart

abnormal thymus epithelium morphology ( J:177992 )

• thymic medullary epithelium primordia present at E13.5 and E15.5 but later development is blocked

• cortical epithelial primordia do not develop

athymia ( J:33796 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
T-cell immunodeficiency, congenital alopecia, and nail dystrophy		DOID:0060769	OMIM:601705	J:33796