Phenotypes Associated with This Genotype

Genotype
MGI:2175037

• Allelic Composition: Gabrb3^tm1Geh/Gabrb3^tm1Geh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:130259 )

• frequently seen sleeping away from nesting material

abnormal response to novel object ( J:130259 )

• increased time until first contact with a novel object compared to wild-type

• decreased amount of time spent investigating a novel object compared to wild-type

decreased vertical activity ( J:130259 )

• total number of rearings differs from wild-type littermates and C57BL/6J mice but not from 129X1/SvJ mice

• the mean duration of each rearing event is decreased compared to controls

increased locomotor activity ( J:130259 )

• a higher degree of ambulatory activity than control mice

• a higher number of entries, in regards to the total transitions between all chambers, of a social interaction apparatus

circling ( J:130259 )

abnormal social/conspecific interaction behavior ( J:130259 )

• fail to show a significant preference for spending time in the interaction chamber adjacent to the stimulus cage containing an unfamiliar mouse as opposed to spending time in the interaction chamber adjacent to an empty stimulus cage

• mice fail to exhibit a preference for interacting with a new mouse over a familiar mouse

abnormal nest building behavior ( J:130259 )

• at 1, 24 and 48 hours after introduction of new nestlet material, mice utilize significantly less material than wild-type controls

• significant impairment in their ability to achieve the nest complexity exhibited by the controls

• location of nest construction is different

nervous system

abnormal cerebellum vermis lobule morphology ( J:130259 )

abnormal cerebellum vermis lobule II morphology ( J:130259 )

• significant decrease in the surface area

abnormal cerebellum vermis lobule III morphology ( J:130259 )

• significant decrease in the surface area

abnormal cerebellum vermis lobule IV morphology ( J:130259 )

• significant decrease in the surface area

abnormal cerebellum vermis lobule V morphology ( J:130259 )

• significant decrease in the surface area

abnormal cerebellum vermis lobule VI morphology ( J:130259 )

• significant decrease in the surface area

abnormal cerebellum vermis lobule VII morphology ( J:130259 )

• significant decrease in the surface area

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:130259